Thresh vs Yorick
First lets look at the lore. Yorick is searching for Ruined King in order to end the curse of the black mist. Thresh on the other hand is sort of responsible for the curse. In Hecarim's lore we see that Thresh helped the king bring back his dead wife with the magical artifacts in the vault. However, she was in a state of despair and begged to be put to rest. This pissed the king off and he cast a spell that would allow him and his queen to be together for eternity; but it amplified by the many magical artifacts surrounding them. With that said, I feel like these characters are bound to have their stories intersect at some point.
Now, based on lore, who do you think would win in a fight? I'm actually not sure, cause Thresh can yank people's souls from their body but Yorick can also command and army of undead.