I thought that Vi was a great addition to the skin line. I never got the feeling that Project is about technology taking over the soul, more about the big questions of transhumanism.
If I can transfer my mind and personality into an artificial body, am I still human?
It's one of the leading questions in Ghost in the Shell, which is a big inspiration for that skin line in my opinion.
While champions like Jhin, Vayne and others (like shown in the short story) rely on augmentation without questioning it, Vi is different. She is a cop who wants to rely on her own abilities instead of using an upgrade.
So in my opinion, there are still alot of champions who could fit in that universe.

But I would prefer to stay with human champions only. So Wukong would be ruled out for me.