You're only delaying your inevitable death by 2.5 seconds, meaning you respawn 2.5 seconds later and that's the only thing you'll ever achieve with it.
Respawn timers are often longer than ult CDs or item active CDs though.
LoL isn't DotA where you have buyback, teleport on everyone, and monster cooldowns.
You're a lot better off using everything you have rather than curling into the fetal position and taking it, especially considering you're not really dead until you're dead in LoL.
Using Shyvana's ultimate to escape is better than just dying.
And most AP champions have ways of damaging targets while they are within Stasis. Heimerdinger, Annie, Zyra, Morganna, Karthus, Brand, Kennen, Swain, Mordekaiser, etc.
If you can force a 1 for 1 when you're outnumbered, you really limit the capacity of your opponents to turn it into an advantage.
And you can bait a lot of damage with Zhonya's. If you're worried about cooldowns - forcing multiple hostile cooldowns because you blocked an R puts your team at a significantly better place for those 50 seconds you're respawning.