What is the hardest thing to react to in league? (Fastest)
Just curious so I can keep a heads up when I try to zhonya dodge. I anticipate some abilities rather than reactive dodging.
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Annie ult im pretty sure has near to no warning beyond her small animation, with the spell instantly stunning/damaging.
Maybe someone coming out of invis to attack such as kha or shaco who have no (obvious) warning or indicator where they are before they melee attack.
Those are the 2 that I can think of.
Thankfully the 2 of them can easily be anticipated, Kha and Annie have a tendency to either flash or leap before using it. Shaco has a little poof particle effect when he uses Q.
Personally though hardest thing for me (playing fiora so parrying cc) is urgot's dash or rakan ult when im in melee range.
AP 
Flash+R
Full ms 
ultimate while you are low
Crit Backstab.