Some of the rune choices are underwhelming.

Precision

PTA generally outclasses the other keystones. LT has some awesome fringe cases, and FF can work for chasing, but 12% damage amp is just insane for how easy it is to proc.

Triumph is the best in its category. Presence is niche, while overheal is garbage.

Coup de Grace is the best in its category. Last Stand is good on Karthus and Trynd, while Cut Down is just bad. This entire category could use a rework, since it's all just boring damage amp.

Domination

Solid choices all around. Good job here. I'd prefer if Cheap Shot and Sudden Impact had more obvious effects, but they're fine.

Sorcery

Phase Rush is just a worse version of Stormraiders. Doesn't hold up the same way Electrocute did.

Manaflow band outclasses the other runes a bit, but those are still viable so It's fine.

Waterwalking is pretty poor because it just doesn't help at all if you're in lanes. Scorch utterly outclasses gathering storm at the moment, but I can totally believe that it's just because of the early game meta we're in.

Resolve

Aftershock outclasses both other options. All tank supports have some kind of stun, so they proc it easily and prefer it over Guardian. Non-tank supports will just run Aery instead of Guardian to achieve a similar effect. Tanks/bruisers looking for a resolve keystone will always run aftershock if possible, only begrudgingly resorting to grasp if they can't proc Aftershock easily.

Except for Demolish, none of the lesser runes are very exciting. Some of them are plenty strong (second wind, unflinching), but they're just boring.

Inspiration

Glacial Augment is good on a couple champions (Gnar and Teemo primarily), but is just outclassed by other runes in almost all cases.

Minion Dematerializer is shit. It's 9% damage amp to half the creep wave at most, and it takes a full minute of spamming them to use all of them (potentially more if the creeps you want aren't present). It's meant to be used on champions like Vel'koz who get through lane by nuking down the creep wave, but it's just not good enough.