Proposed base mechanic to help with high latency and optimization of combos
This is a mechanic from Dota called "Shift-Queueing", and it's pretty simple.
If you hold shift and then enter multiple commands in advance, your character will execute those commands in order.
For example, Fiddlesticks could press Shift--R-Flash-Protobelt-Q on the carry, and he would flash the moment after he blinked with his ultimate and protobelt+fear the enemy carry nigh instantaneously, minimizing the crowstorm time wasted in transit.
Nocturne could do Shift-R-R-Q to fly onto the enemy carry and Q on arrival.
In a more mundane scenario, you could Shift-queue movement and attack move commands to clear the jungle on high ping.