The age old question of mpen/apen?
I've been messing with my rune pages and googling an answer for this. In general I've seen that characters with low ad/ap ratios want penetration runes.
However, there is still no straight answer for characters who are in the middle somewhere. It seems like apen/mpen should give more overall damage, but other people claim that's only true at low armor levels and you should always go AD, others say pen scales better and you should always take it instead. Especially on ADC's I'm seeing an overwhelming amount of players take the pure AD rune route.
There are enough variables that it's not as easy to just calculate it out like you would with some runes (or ad vs attack speed for that matter). Is there some threshold where pen becomes better than ap or ad runes? What is your experience?