My main gripe with preseason
Masteries? Yeah, thunderlords is overshadowing everything else, but that is not it.
Champions? Yes, I have a deep hatred of Rengar/Fiora/Fizz, but that is not specific to this period.
Items? Sure, I miss green wards, and see far too many FQC's and rageblades, but I can deal with that.
My problem with it is the matchmaking. Seriously, something is wrong when I look on op.gg to find that plats, diamonds, bronzies, and pre-30's are being put into the same match. High tier players have to deal with their team making dumb calls ("hey let's towerdive the Morgana!") and low tier players just get destroyed by grossly unfair matchups ("I don't even have a complete rune page yet, why am I laning against a Plat 2 Viktor?").
Personally, I am irritated by how I can't test things in normals to get a sense of how good it actually is (Sure, that build works against people two tiers below you, but will it work against players at your level?)
edit: this kind of thing gets on my nerves. http://imgur.com/xsfVCzM