Tertiary Rune Path
I believe that tertiary Runes are a good idea, so that we can select one Rune (not a keystone) from a third Rune Path. For example: I would select Domination as my primary Rune Path with Dark Harvest as my Keystone, along with Cheap Shot, Eyeball Collection, and Ultimate Hunter; Sorcery would be my secondary Rune Path, with Transcendence and Gathering Storm; and Inspiration would be my tertiary Rune Path, with Cosmic Insight.