[{quoted}](name=Slamurai Jack,realm=NA,application-id=3ErqAdtq,discussion-id=bfnM6t0b,comment-id=0004,timestamp=2015-12-26T06:23:04.671+0000)
You don't beat Brand with assassins. You beat him with longer ranged mages. Vel'koz, Xerath, and Lux are what you're looking for, not Zed, Talon, or Leblanc.
Whenever I play Brand, Zed is a difficult matchup. This is because unlike other assassins, Zed can dodge Brand's abilities with his shadows and his ult. Granted you must play Zed really well to do that, but a good Zed is nearly impossible to deal with as Brand. Also, you are forced to rush a Zhonya and this can delay either Rylai or Liandry. Unless Zed does not manage to get fed, of course, then Zhonya will not be necessary.
Other assassins that are difficult to deal with are Fizz and Rengar. Fizz for the same reason as Zed: he can dodge everything with his Playful/Trickster. Rengar is not obviously going to lane against Brand, but a jungle/roaming Rengar is difficult to deal with. He can come from nowhere, and he instabursts Brand, not giving time for Brand to reply with E + Q and survive.
It's true that Brand can beat assassins due to his kit (like other immobile mages which are surprisingly good against assassins) but this does not mean that Brand can deal with every assassin. Picking a mage that can outrange him, or Veigar, will provide more consistent results, but there are other ways to deal with Brand.