How are melees supposed to fight
Tumble + stealth + knockback...
Anyone? 
Tumble + stealth + knockback...
Anyone? 
u wait for ur tristana to 3 shot her from an even bigger range then u go in
Punching and slashing nornally.
...yes, because all melees fight the exact same way, and can totally be put in one category.
CC her.
Burst her.
Gank her.
End before she hits full build.
Bait her ult and disengage.
Bait peel spells and disengage.
Kill her peel.
Don't let her fight you all one at a time.
CC her.
Kinda hard to land skillshots on her when she has a dash + invis every 2 seconds.
Burst her.
See above. Vayne at 2.5 items bursts harder than 70% of champions in this game. Well any ADC does, but that's because the entire class is as busted as old Olaf was and deserves an appropriate gutting.
End before she hits full build.
She might as well be full build at 2.5 items.
Amen!
Get sweepers. If her position is revealed, unknowns are negated.
Vayne doesn't have burst anymore, not with the Q crit removed. She has incredible dps, but no burst.
Vayne with two items is about as strong as any other ADC with two items. After that point, she begins to outscale most of them.
Vayne doesn't have burst anymore
Dude she's a fucking ADC they all have burst because you get burst from building Shiv. She has incredible DPS that is as high as an assassin's burst.
Vayne with two items is about as strong as any other ADC with two items
Yeah, too fucking strong. For the amount of power that ADCs have, they should have zero game impact until at the absolute minimum 3 items. 3.5-4 for hypercarries like Vayne.
Just because it leaves a revealed position doesn't mean you can do anything about it...
Here was me thinking oh! She condemned a minion! I can fight this! Yeah no. She comes out of fight full HP w/o burning a summoner.
Credits to Sona, Ardent, Vayne, and Riot
I mean. If Sona and a Lux shield couldn't keep her alive through one person's damage, that'd be completely bullshit. Especially when that 'one person' is a Jax with one damage item.
Why do people expect they should be able to 1v2 easily?
Supports are a team member too. You shouldn't act as if you can just ignore them.
You lost a 1v2.
If you had won that easy, it would have been bullshit. That was just poor decision making.
If anything, you should have killed the Sona first so your teammate could swoop in and save the day.
Surpress her.
Oh wait 
Ban her. Only counter.
[{quoted}](name=K9 Unit,realm=NA,application-id=3ErqAdtq,discussion-id=WTO6XyFk,comment-id=0001,timestamp=2017-10-12T07:20:55.571+0000)
Ban her. Only counter.
Now if only I could figure out why Riot removed most of the counter play to adc's but adc's can still just right click sidestep their way to victory.
Ghost works to some extent, plus Sweeper against the stealth. Yeah, it's not easy, but it's not supposed to be. What's important is that you can do something, you're not just virtually dead.
And this is assuming you want to 1v1 her. But sometimes, the good plan is just to not try and 1v1 her and to just play for big 5v5 team-fights.
She's one of riot's many "Lol you want to play a tanky fighter? In OUR game?" champions.

Counterplay is a one way street in this game because they balance champions around the assumption that they can't kite (so low elo is balanced) and just expect high elo to know better than to pick archetypes with hardcounters.
Pick Nasus, other than that you really don't. Vayne was the champion that was before Fiora as in "they can out duel everyone." Due to the nature of their kits while both having %true damage health and dashes you don't 1v1 them as melee or really as any champion. You have to fight in a 5v5 setting.
Isn't it lovely how this piece of garbage continues to live pretty much untouched when other champs have been gutted and reworked for less "offense"? Vayne is a terror since forever and she always rises up to broken unfun tier.