The Teemo problem
Also applies to Jayce, Kennen, and any number of ranged bullies.
Earlygame as a melee champion, you can't farm caster minions vs them or you get chunked down to half health off 1 trade. Under tower you're forced to concede caster CS or get half of your HP chunked off 1 wave. Your first back is somewhere between 200-400 gold less than them.
First back you buy defensive stats just to survive csing, your lane continues to be a passive lane where you farm under tower, get poked out and then recall. Gold deficit falls somewhere into the 400-600 range. You're also probably down on levels at this point.
Midgame, a team fight breaks out and you have
to their
. You can't 1v1 them because they have a gold/exp lead, you can't split push because their 2v2 beats yours, so you're stuck to following them around the map and hoping for a winning teamfight.
Lategame, they probably have 50cs lead on you or more. Well this is where I truly shine right? I'm a bruiser and I'm finally tanky enough to survive their damage. Well would you look at that,

actually scales well and 1 shot my team. Feelsbadman
Also
chunked our ADC to 1/2 health with one EQ
Also
auto Q'd our mage or ADC, and they're 1/2 health (and we can't hard engage due to shrooms)