What if Master Yi's Q procced on-hit effects?
If the aoe on-hit seems too op it could be limited to the primary target, though I'm not convinced that's necessary - while it's possible it would break Hydra on him on clumped targets, there are much more powerful ways to abuse clumped targets.
I can't see it being more busted than any abuse cases Twitch and/or Runaans have - sure he's untargetable, but that doesn't really interact with on-hits.