Well from a statistic point of view the relationship between Play rate and win rate is that the lower the play rate the higher the win rate as it should be only mains playing the champ. When a champ has a high winrate and a high play that is normally an indication a champion is providing too much of a success rate and a possible indication they may be too strong.
When it comes statistical analysis involving outside/unknown or uncontrollable variables the best way to counteract that is randomisation which is technically applied in your league matches as the teammates and the champs they play are all random therefore solving this issue. All champs statistically have the same randomisation applied to their stats as well and are therefore technically on equal footing.
https://en.wikipedia.org/wiki/Randomization