[GAMEPLAY] Game won't register mouse click input after Patch 5.5

This usually happens about 20-30 minutes into the game. Suddenly, my attempts to move my champion around by clicking stop working. I cannot click the store. I cannot do ANYTHING that involves clicking my mouse. I can, however, use SOME of my abilities. For example, as Rek'Sai, I can make tunnels and use my ultimate. However, I can't press Esc and access the menu.

No, this is NOT a problem with my mouse. I can click everything on my desktop just fine when I minimize the game. This bug only affects my interaction with the game through mouse clicks, and also certain key presses like Esc.

To reproduce:

1. Play several games.
2. Experience random loss of ability to click mouse late in the game. Not sure what the trigger is.
3. Fail to open menu. Still able to use certain abilities.

I have to quit the game and reconnect to get this issue to stop. Only once has my mouse input come back without me trying to quit, and it took about 5 minutes for this to happen. The game was threatening to give me leaverbuster too for being AFK, which is kinda unfair, lol.

Anyway, this is a really bad bug. Please fix this. :(

Thanks!