Added this section after I noticed you appear to be lacking in runes. Rather than making rune pages specialized for champions, I would recommend making two basic, general pages first to cover most champions.
AD Page: AD Marks and Quints, Armor Seals, MR Glyphs
AP Page: AP Quints, Magic Pen (or AD if desperate) Marks, Armor Seals, MR Glyphs
If you want them to be even more generally applicable, it might be worthwhile to take one Armor Quint (the rest normal) and use Scaling Health Seals.
These are all cheap runes and will cover most champions relatively well, though not always the most efficient. You can build specialized pages afterwards.
For Nasus, I typically use:
- Flat CDR Quints
- Flat CDR Glyphs
- Armor Pen Marks
- Flat Armor Seals
Flat CDR helps you stack early and lets you cap out on CDR very early (either Frozen Heart, Black Cleaver, or Glacial Shroud and Kindlegem), which improves your damage and sustain. It's quite possible to hit 200 stacks by 10 minutes against an easy lane, which can make you a monster mid-game,
Armor pen provides Nasus with a lot of damage because:
- You purchase Sheen
- Your Q stacks deal physical damage
- Your E reduces armor
- Your ultimate grants AD
The seals are mostly there for early damage reduction against autoattacks and minions.