I dont believe in mixing runes, it just kinda grosses me out. I f you wanna know the champs i play, they arent all 6300,
top: i avoid at all costs.
mid: Diana, vel koz, fizz
Adc: Jinx and Sivir
supp: Braum and Sona
Jg: rammus
these are all over the board for pricing, and honestly, the only one worth the 6300 in ip is jinx, followed by diana in terms of power.
I dont start d ring on fizz, because i take too much poke, so i get flask. Maybe try that on wu, its a safe item, i dont really play him, but it may help you. Also , if you are vs. a range auto attack (ie corki(seriously top corki happened to me once) nid, gnar, pick d shield. Its an odd item, but i always notice a difference. Also cloth five is a good start too.
I would say you need to pay attention to the minions. If you trade back when the enemy has more minons lvl 1-3 you take more damage by a significant margin. I got first blood once by literally playing chicken and they zoned me out of my minions by standing in them, while taking aggro. I dashed in (i was renek) and got first blood. Minions are really good early.
I suggest
, myabe try it and see how it helps. If you always get zoned and poked, you are doing something wrong. You should be able to get some cs. ALso trade with them when they last hit your minions, its will allow you to get free damage on them