I think Karma is simply some sort of... idol of Ionia, someone who through her choices has been recognized as a wise but powerful woman, in short, the enlighted one.
She has a sentence that I think defines her "trope": I've seen two paths and made another between
She isn't much of an spiritual leader but just some sort of pacifist that leads through example, I say pacifist because she is heavily against violence but she is also heavily against sitting idle, she fights with calm resolve and overpowers her foes through sheer willpower, hence why drain tank Karma seems to work wonders lol
edit: I wanted to add that, most of her kit is in fact very reactive with the exception of Q, this is because Karma's theme is in fact the willpower pacifist, you can hit her all you want but you won't get anywhere (in theory) she will stand there (drain tank + shield) taking a beating until you tire yourself out and then she'll slap you and tell you: see? I told you, you can't win. And then she'll burst you out of her temple with a Q in the face