Hm, there are some coming to my mind.
Bloodmoon Camille
I think she would work really well in that skin line. In my imagination, she is based on the ghost tale of the kuchisake-onna. White mask with a mouth that is slit wide open, her legs are each one half of a scissor. Chains with kunai at the ends for her hookshot. Her passive would be either a blood orb swirling around her (AD shield) or blue ghosts (AP shield).
Chemtech Sejuani
I would absolutely love a chemtech motorbike. Basically Sejuani as a Zaunite, chemtech driven motorbike instead of bristle. Her weapon is a flask with green goo on a chain. Passive lets the tubes on her bike glow green if it is active and the Zaun crest on top of her. Q is a wheelie, E covers the enemy in green goo instead of ice. Same with R, instead of an icestorm in the area there are green fumes.
Star Guardian Caitlyn & Vi
I want them to be together in a team of Star Guardians. They would be so great. Caitlyn is the intelligent, responsible class represent. Vi is the always brawling tomboy. They always hang out together and no one understands why, since they are so different. Maybe hinting even some romance here, it would be so god damn cute.
Boneyard Urgot
Halloween skin. Urgot is an unholy abomination built out of the bones of different creatures. His arm cannon is the skull of a dragon and it shoots blue ghost flames. For his ultimate, he is opening his ribcage and his rips start moving like teeth, tearing you to pieces.
And the most unrealistic one:
FEMALE ZAC
Give me a sexy slime girl like Suu.
https://images-cdn.9gag.com/photo/a0KmRPd_460s.jpg