5 rune concepts
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Sorcery- the further your skill-shot travels from your character the more magic pen is applied to the ability.
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Resolve- gain adaptive damage depending on the amount of damage u mitigated.
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Domination- after killing (x) number of minions your next ability deals a small amount of extra damage exclusively to champions (am not good with numbers so, i left alot out but id say around a extra 10 50 depending on level)
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inspiration- hextech siege, this item is a once a game deplorable minion that gives u and allies extra attacks speed moving with the minion line but deals no damage itself. (aimed to pro play supports who can lead the game in a role that has minimla turret interaction normally.)
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precision- if you auto attack (X) amount of time on any target u will being to heal a stacking flat amount.
Mostly just spit balling some ideas so we can get some runes out there, i wouldn't say these are 100 percent unique but i did try to make a mental effort to defy the comfort zone of just numbers.
to start 1 shoting because he took two tower shots) but as long as the cool-down was long enough this would be good.