Seems like every spiderman thread doesn't make more than 5 minutes before it turns into a unicorns/Dio/deadpool thread :/
With Deadpool its funnier since he is actually friends with Spiderman!
Pretty sure he kills him in the comics among with all the other superheroes for mistress death...
They had an imagination fight and came to a draw. My friend told me about that and it made me laugh!
That was in the animated series. There is however a comic called Deadpool kills the Marvel Universe, where, you guessed it, he killed everyone.