Skin Swap
You'd get a lot of funny situations grafting champs skins onto each other (let's assume the animations are modified so that it makes sense). For example, Annie as Lee; the small child dashing everywhere and kicking you across the screen. Comment with whatever funny imagery comes to mind.
Mine:
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. You tackle people with this bigass spaceman and swing the anchor like a flail.
Also honorable mention
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. Q makes him do that arcing faceplant like a jumping bean, and R lets him draw in the blood of his foes like the true demon he is.
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. Seeing the big fluffball roll around at mach speeds would be great.
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