Cassiopeia Idea with the poison amp
What if the poison amplification from her E, instead of being a debuff on targets, was a stacking buff on Cass herself? Obviously there would need to be some tweaking, but it could make her poison seem more potent without necessarily having to close distance as long as you were good enough to maintain your stacks (skill!). Hell you could maybe add on a mana cost reduction effect to "bring back" deadly cadence and help her not go viciously OOM later on.
Just an idea that came to mind.