Make it so you can force interact by for instace using left click
What I mean by that is make it so that using left click would do the same as right click, but have a different hitbox prioritization. Left click would prioritize interactable champion abilities > wards > plants > towers > minions & monsters > champions, and right click would prioritze the exact opposite way around. This way you could use right click for offensive play (aka attacking enemy champions with basic attacks or onclick spells) and left click for more defensive plays (clicking a Thresh lantern, farming under a champions feet without accidently drawing minion aggro, etc)
Maybe bind it to a different button but you get the just of it. It would reduce the amount of annoyance over misclicking on the wrong hitbox :D