My ideas of the secondary rune tree
ADC that needs sustain in lane -Primary precision with fleet foot -Secondary resolve
ADC that scales with AS -Primary precision with lethal tempo -Secondary resolve
Burst assassins -Primary Domination -Secondary sorcery or resolve
Mage not burst -Primary sorcery with meteor -Secondary resolve or domination or inspiration
Mage with shields -Primary with aeries -Secondary resolve or domination or inspiration
Tanky bruiser -Primary resolve -Secondary precision or domination
Tanky initiator -Primary resolve -Secondary sorcery
Tanky support -Primary resolve -Secondary sorcery or inspiration