Ultimore Rune and Karma
A new non keystone has been revealed recently and has currently the following effect:
Ultimore: Gain 5% cooldown reduction and maximum cooldown reduction on your ultimate. This increases by 1.5% each time you cast your ultimate. Stacks up to 10 times.
I can predict, that it will totally break Karma. You are casting Mantra (R) very often and its core to her kit. Furthermore you can easily get the full +20% CDR even quite easily before the 15 min mark.
Since runes reforged will most likely happen before a Karma rework, Riot will nerf Karma to compensate this insane boost coming from this non keystone - most likely her Passive which makes it even less worth as a Stand alone "skillexpressing" Passive or Mantras Cooldown. It will force this non Keystone as a Core Rune of Karma.
Mantra at rank 4: 36 seconds cooldown With 45% CDR: 19.8 - a good Karma has a Mantra every ~6 Seconds With 60% CDR: 14.4 - would be around 4 Seconds.
Just my thoughts... what are yours?