yoyooyo im here,so for the runes part you need magic pen on the red ones,on the yellow ones you go full hp on the blue ones you go full ap and on quintess you go full hp.For masteries you go with deathfire touch because whoever told you vladimir is a champion that does a combo is a stupid noob vladimir is hard poke and strong mid-late game,and you need the mastery with 1%more dmg for every unique enemy champion killed not double edged sword.Also after you go for the resolve and since i dont know the names too well im just goona go like in the tower:Left>middle>right>middle.And the first item you have to buy is actually ruby cristal and you will go around 850-900 hp like that in lvl 1 and you will be almost unkilable.Btw dont do this(W+E) its too stupid and if you want to dodge something with your w to deny dmg,dont you will lose more hp using your w than the enemy doing damage to you,you have to keep your w for 3 reasons:CC when the enemy ganks,When you are diving,and you use ghost+(R,W,E) inside their team and let the team do the rest of the dmg because you already took at least 50% from all their health(except tank).For items the only full hp item you have to buy is warmong(use your passive clever) and for the build you go like that
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(i know it sounds stupid but if the enemy has a lot of lifesteal it will help a lot believe me) OR
you should be around 4000-4500 hp with the build and 600 ap(oh and q+E is enough to kill almost everybody in late)btw you have to be the engager and mostly you have to engage with your ult,try catching as many as possible