Vayne needs the Rengar Treatment.
Being the fact that she's a Mana reliant AA focused champion (how is this possible?) I find her to be a bit on the weaker side. Vayne is extremely difficult to play so she should be one of those champions that can 1v5. But she has a little trouble with cc. Maybe you could work some of that E-bola magic (I know it's not his but it's an opportunity that people shouldn't throw away when they can use it or even just mention it), so that her kit is a bit more cc 'friendly'. Sooooooooooooooooooooo why not make it so that during her ult she can't be hard cced. I mean like she is squishy like wet toilet paper on fire. So why let her have to get so close with her mediocre range and able to be blown up so easily.
Also her Q range needs some love too. The range is just too short. Make it the range of teemo's blind and then I guess it would be alright.
