What about a defense item that halves magic damage taken but doubles physical
(or vice versa) I don't think it would be broken because even if someone built this against an all AP team, a player on the AP team could still improvise a sub-optimal physical damage build and get a lot of value from the physical damage boost.
An item like this would allow builds previously reserved for only the most toxic of trolling to become legitimately viable across all elos. Could be a fun addition.

a Small inch of MR on a tank makes me do 0 dmg so I don't even need to send my skillshots anyway