Can we have a mode where....

That game is called Heroes of the Storm.

so people who can't CS to have a chance?

I imagine it would be pretty bland, also a waste of a game mode to be truly honest. Sounds like something you'd want to do in a custom. Though I am curious to try this out with a bunch of friends.

I imagine most champions would not hit much of a power spike. the ones that would thrive are champions that have innate increased damage or amplifications of moves where they don't need to rely on items.

that's called first time playing.

Tryndamere becomes god.

I do that already except for the items.

How about no runes and masteries, but we keep items?

I dont see this working because of how one sided some champs are early to late game. Some champs are useless early game, while others are lane bullies and harass you early. This mode in my opinion would just make this more of an issue.

Example of this would be like a Riven vs Vlad top lane. Riven would dominate Vlad, but once vlad gets some CDR and AP, it becomes a more advantageous fight,

and do you really want no items against a teemo? blinds and poison for days.

no items ahri only final destination?