your biggest issue would be that kayle has to engage. either yuo burn your ult and get at most 5-7 attacks (because they can't instantly target you once the buff ends) or you build tankier. another problem, runaan's doesn't work on her other than as an attack speed item
with this build, you would do a large amount of minimal sustain damage ( almost 200 physical damage - armor, then 8% of current health minus armor) then 42 magic damage, then approximately 90 damage from E, so you would be doing around 300 damage per hit at most, even squishies would require 7 hits to take out with this build, many, many more for a 5000 hp tank