It depends what you mean. Hardest champion to play the champion or hardest champion to play the game with?
Hardest champion to play the champion is probably
because of her auto attack canceling and numerous other mechanics that have unnatural interactions. That said, she's heavily compensated with her AD scalings on everything and her mobility.
Hardest champion to play the game with is probably
because the player has literally no agency or kill pressure. He effectively has 3 skills his passive (which is now worse than a standard spell shield), Q/W/E and R. He's Q/W/E, can literally be bound to a mouse macro. Yet all of his kill potential is based on if the enemy uses their escapes to engage and if they don't do any damage to your glass voidlings.