Help on Nasus?!
Does anyone know what runes and build should I take to play D CANE 
I want start playing him
Does anyone know what runes and build should I take to play D CANE 
I want start playing him
This is the setup I used when I played him (though it has been a couple months):
While AD marks may help you last-hit early, you should be able to do without them with a little practice. At that point, Armor Pen marks are far more valuable since it will make the damage provided by Q, Sheen and your ultimate (AD) far more valuable.
Lifesteal is pretty nice for sustain. While you already have some from your passive, the additional healing is quite helpful.
AS quints AD reds Flat MR blues flat armor yellows. Go 0/18/12 taking stormraiders
You should focus on building tons of tankiness in runes and in-game items. Your damage comes from your farming your Q up, and your cc is just the W. Just frontline, scare those enemies off when they're trying to protect towers.
I am a Gold IV Nasus Main for reference.
Nasus's damage is 60/40 Attack dmg and Magic Dmg. So:
Masteries- ALWAYS 18 in resolve Storm Raiders only helps against slows not all CC. You want the tenacity in the Resolve Tree as it stacks with Mercury Treads and Elixir of Iron. I prefer 12 in ferocity but you can benefit from 12 in Cunning, it is really preference. I personally like the extra LS, AS and damge on slowed targets.
Your sheen item should always go to IBG. TF takes too long to build, too expensive and split pushing is not that valid of a tactic this season. Build him to be able to push large waves by mid game and helps his team peel and take objectives. My personal build typically looks like this.
. This is a great all around build and is essentially the order I build in.
Best of luck m8!