Your Nerf to Vayne is not gonna change much
The changes: Stealth duration cut in half (1>0.5) And Tumble (Q) bonus damage lowered to 10/25/40/55/70% AD from 30/40/50/60/70% AD.
Why would this nerf barely change anything? Well, the problem with vayne right now is her ability to burst tanks and squishies alike with the combination of IE+shiv crit, she can pretty much outduel every other ADC from mid-late game (if she isnt behind that is).
These nerfs, dont fix anything, vayne's super early game will be weaker, yea, but it always was. But by the time she gets IE she'll be almost at the same state, and with shiv she'll burst everyone just like before - this is unhealthy for a tank busting ADC - her damage should be comming from silver bolts, and Q for a repositioning tool and a bit of poke, not a ranged burst tool.
What should be looked at is her late game scaling of Q, revert the stealth nerf, no one was abusing duskblade on vayne, thats such a niche build it's not worth getting into.
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