I am really getting sick of this -_-

Every time I start my first game after logging into League, game, I have to left click everything 3 or more times, and I can't lock or unlock my camera using my hot keys. This has been going on for who knows how long, and the only way I can fix it is by relogging. This glitch used to occur rarely, but now it occurs EVERY... SINGLE... TIME! I play the game on a 2009 standard MacBook running on OS X Yosemite.