You're trying to poke down a champion that has a shield that's constantly refilling? Don't see your problem! 
Seriously though, chances are he started
and is rushing a
. That's a massive amount of sustain for a mid laner. You're not poking that down, especially since Morde has no mana to run out of. He's very weak early game, so go all in and be aggressive when you think you can. Once he gets his ult, that's when you know it's time to hang back and take it easy. Feel free to roam at that point, since there's no way he can follow someone with mobility, and even though he can push lane like a champ he can't deal damage to towers well.
Also remember that Morde has 0 cc and 0 mobility, and his AoE abilities tend to push the lane. This is perfect for a quick call to your jungler. When Morde gets ganked, he either burns flash or stands and fights until he dies; no running away for his slow ass.
Keep in mind that any cc that prevents him from casting (silence, stun, charm, taunt) will stop him from regenerating his shield as well, leaving him open for the pain.