Darius is one of those champions that you need to build conditionally for, actually.
This.
For tanky opponents, build brutalizer -> Black cleaver.
For AP opponents, start longsword + red pots, and build hexdrinker right after.
For general opponents that don't focus the other two, doran's blade is more than enough.
Your objective:
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Use Q to harass and trade.
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Use bleed as a means of exchange through it's mspd steroid of 5% per champion.
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If you don't feel confident against your opponent, don't take ignite, take teleport.
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Always ignite after you dunk if you don't think you can kill them with just your dunk.
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Have vision of your lane, the enemy will always call for a gank because you're Darius.
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Combo: EWQR.
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Skill order: (R)QWE.
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End game builds are entirely situational for Darius, he could snowball and have shit tons of damage, or he could fall behind and go tanky.
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Fit your team's needs rather than your own if you can't snowball. This should be a given regardless if snowballing, but Darius snowballs really hard because of R.
Lane match-ups:
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Teemo: Seems impossible, but it's not, phage, hexdrinker, and landing any bleed damage on him is more than enough to catch his furry ass and dunk him to death.
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Cho'gath: Hard as balls lane, get mobility and abuse his positioning strength, and turn it into a weakness.
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Riven: Use bleed's mspd to bait her Q combo and out run it, mobility will help you out exchange her post 6.
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Garen: Don't be fooled by his passive being negated by bleed, he's still a lot tankier than you, ganks may decide this match up.
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Nasus: Nasus can be harassed easily early, until he builds armor, continue to harass him throughout the game so he doesn't stack up, making his tanky build useless outside of being a meat shield.
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Quinn: She might be ranged, but she doesn't build tanky, start Q, then E at lvl 2, and abuse her gap closer with QE.
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Gnar: Gnar is the definition of "anti-fun", he has sustain from Mega gnar state, a reliable escape, poke, hp based damage, and hard cc from his mega gnar state. Force gnar's mega state post 6 where he has no mobility and his escape is unreliable, pull him when he tries to escape and QER.
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Jarvan: Jarvan has very strong exchanges, mostly because of his armor shred and hp based AA's, building tanky and staying passive or getting a jungler would be a good idea.
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Akali: Always start with ignite for this one, because you can abuse her for staying in her stealth shroud by applying bleed and ignite, it won't reveal her, but she will not want to stay in that shroud. If you can, pull her when she tries to escape and/or dunk her.
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Ryze: Ryze scales hard if you let him, start Q then E to force him out of lane, the longer it takes him to build up his tear, the better.
My Build Path:
If I snowball super hard, there's items like Mercurial Scimitar that work really nice against champs like Annie, Malz, or Warwick.
My best end game build is: Mercurial Scimitar, Ninja tabi (homeguard), Black Cleaver, Ravenous hydra, Omen, and finally Triforce.
Explanation:
Mercurial Scimitar: Super snow ball item, don't build if you're not snow balling. Effects of QSS that removes shit like Suppress or stun. B.F. Sword bonus damage, great MR gain, slight mspd steroid.
Ninja tabi - Usually to deal with the enemy adc's damage while they try to kite you. This blocks 10% of any on-coming AA damage of any damage, even true damage.
Homeguard - It's usually the best tool to pick up as darius, unless you're really thirsty for blood by buying Furor, or need to be globally present with distortion. Don't even think about captain.
Black Cleaver - Usually replaceable with Last Whisper, however, the extra health from it is very beneficial and armor shred helps the whole team damage the target. Getting multiple armor shreds on multiple targets is much better than piercing it yourself.
Ravenous Hydra - Sustain, crazy good damage, wave clear. Doesn't apply blood stacks to multiple targets, but helps deal overall damage in team fights/
More later.