A common misconception is the vastaya are furries. Actually they are shapeshifters. And notably most of the creatures which inspired the early champions in this group are shape-shifters too. (A kumiho, the monkey king, a werecat etc..)
The vastaya are often in a shape that they have chosen both consciously and unconsciously based on tribe, environment, and personality. They can change shape depending upon the availability of magic, amount of time required for the change, and in the depth of their connection to their ancestry (vastayashairei).
So a radical change that might take Rakan three days, totally exhaust him, and be hard for him to hold for more than a few minutes... well Neeko could do that in 2 seconds and hold it for several days. (Thus shapeshifting is a part of her gameplay kit and not a part of his, but in lore they both have some level of this ability.)
The vastaya generally avoid looking purely human or animalistic because it's uncomfortable and not ideal for fighting. (Xayah would find having a human foot about the same comfort and ease as you would wearing 8 inch platform heels, two sizes two small. You could do it, but you wouldn't want to fight those shoes and you wouldn't want to wear them for long either.) But yes this does mean they excell at spying and intrigue.
I didn't work on Sett but, one imagines Sett has some of this shapeshifting ability but it's pretty weak and probably not something he can control very well compared to his mother. (But also that looking more human is easier and more comfortable for him than it is for his mom).
Personally, I would love to see a more human looking Rengar canon skin and a less human looking Rakan and Xayah canon skins... cause it'd be cool to choose a canon skin before the fight.