Freljord V.S Noxus
So in Taliyah's new story -spoiler- she is told by Yasuo to make her way towards the Freljord to meet people there who are currently against Noxus. I am going to go ahead and assume this will be Ashe's faction (Avarosans) of the Freljord since Sejuani/Winter's Claw doesn't seem to care about anything but taking over control of the Freljord. Ashe is much more diplomatic, trying to unite the Frejlord, and no doubt communicating with other super powers in Runeterra.
Now this would mean Demacia sides with Ashe/Avarasons which could mean the Noxians and Winter's Claw could form an alliance as well. But don't forget Lissandra is currently controlling the Frostguard faction which sides with the Avarosans, but we all know Lissandra just wants to freeze the world.
Or, Taliyah could even be meeting Quinn who we last saw having an encounter with Lissandra in the Frejlord. I don't quite remember the story, but I know Quinn was sent by Demacia on a mission to see what's going down in the Frejlord. So perhaps Quinn is stationed there with other Demacians.
And not to mention that Shurima has risen in the present day and Azir is seeking to rebuild Shurima.
Who knows, this could be the start of a Runeterran civil war, a war of runes perhaps, maybe a...Rune War?