When i think at Famine i think at a Female Frontline support ( cause Leona should't be the only one ) mainly focused on debuff ... you know someting like:
Passive: Drain enemy force reducing their movement speed by X% ( scale with lvl with a cap ) for every sec she is near them
Q: Next AA put a mark on the target that deal bonus dmg and stun the target if hitted by an ally after 3 sec ( very close to Seju but only activable by an ally )
W: Negate a Unit from Critically striking for X sec_ ( point and click ability placed here just to kill Yasuo )_
E: A skillshot that apply a new status similar to sleep (_ something like .... If landed the enemy remain harmless for X sec ( 1.5-2 sec? ) or till it's hitted by an ally, your skill and ability won't remove the staus )_
R: Chain herself to the selected enemy sapping his life force_ ( ignore shield, magic dmg, etc... )_, the sapped life force is used to provvide a shield to her and a selected ally unit for X% of the dmg done.
The combo would be pretty clean ..... landing E, casting R and appling Q, when the target wake up he have time for reaction before your adc can go for the stun. As for the lategame she will require coordination but her W and passive will be amazing tool.
Look whise, this ( female version XD ):
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