How cooperative is Mechs vs. Minions?

To better detail the question--

Can the game be played as a "solo experience" potentially without the need for other players? An example would be Legendary Encounters; a deck-building game which, although it can be played together as a team, serves itself as the same and equal experience in a solo-play perspective.

Or does the game require other players for its cooperative elements to function? Two examples of this would be Hanabi--the fireworks game which works like "reverse poker"--or Codenames, the word-guessing game.