Changes to cs, red/blue camps, Kills, and Damage To Towers (Much NEEDED Change in Today's Meta)
I would like to see a change to the game "Kills now permanently grant increased % damage to towers." This would subsidize the value of kills a little as well as ending the game a tad sooner, especially games where the snowballing team has significantly more kills. The effect itself could be built into the towers themselves "This structure takes increased % damage based on a champion's kills".
While I would also like to see a little more gold for cs (and blue/red buffs too) and more gold for kills (this would also end the game earlier and encourage skill), the tower % damage change I think would be the best/most important change and make the most positive impact on the game.