Poke with your Q, but mainly use it when passive is up. If in a team fight, E in, W, then ult yourself. You will deal good damage. When you are invulnerable from your ult it will be the perfect time for your team to engage.
Max Order:
Q
W
R (MAX WHEN YOU CAN)
E
Get Q first, then E, then W. (Get R/Ult Whenever you can)
Lissandra isn't the best against Malzahar, Brand, sometimes Ekko, Zed, Talon, Leblanc, Anivia, and Ahri.
Look Here For More Counters.
She's hard to play at first kind of, but you will eventually figure her out. If played right she can help carry and people will be afraid of her.
Look Here At A Game I Played As Lissandra To See My Build.
I Hoped This Helped! Have An nICE day!
[slayer-jinx-catface]