Wild Rift will have a simplified Rune System with all-new Runes
Wild Rift appears to have a different rune system than vanilla LoL does. You can select any of the keystones and pair them with one minor rune from each row
The first row has Ravenous Hunter, Gathering Storm and Triumph along with three new runes so I surmise this is the Offense category The second row has conditioning and second wind with 4 new runes and because the first one is also Resolve colored I have to guess this is defense Last row features Utility runes as far as I can guess Ingenious Hunter and Manaflow Band make an appearance with 4 new runes once again
As someone who wants more runes for greater variety in the game it sort of excites me at the prospect that some of these COULD make it into League. I doubt it because they're bound to be simplified for a more casual market, but fact that art assets were made brand new suggests they could be ported to over.