So I have been Analyzing the new Ryze being played in the LCS, and it would appear that they are maxing his Rune prison first.

Rune Prison has a 1.75 duration at max level. with a 14 second cooldown. His Q has a 4 second cooldown.

With 20% CDR, these would be 11.2 and 3.2 respectively. and his passive reduces his cooldowns by the cd of his Q.

We can assume that a Q-E-Q is easily performed during the duration of this cooldown. So once his Rune prison goes on Cooldown. 11.2s - 3.2*3 = 1.6 seconds which is less than the duration of the root.

So at level 9 with 20% CDR, Ryze has a perma root, at least for duration of his passive which is 6 seconds at all levels.

Something tells me Riot won't let this be unanswered.