As Riot has created many skins that have gotten fancier, i think that many are an actual enhancement to game play. For instance Some Lux skins make her e less visible, or Blitzcrank skins make his rocket grab harder to see/alter the hitbox. My idea is to add an option to select which skins you want to turn off for that players side. This would not affect anyone else but you individually.
Admittedly, I've run into a couple of issues where the actual effect of the skin makes an attack too difficult to notice, or at least notice on time. In most cases I don't have this issue per say, but when it does happen, it's an absolute pain.
Are you color blind? I could see that being an issue, outside of that, I've never had a problem with any of the skins.
I think this CAN be an issue but its not intentional on riots part. For example when deathsworn 
was released the sound when she ulted was barely able to be heard and the animation of starting her ult was very similar to the animation when she picked up a dagger and aoe'd around her. Riot shortly changed that skin to have more clarity so it would be more obvious when she ulted.
