Potential memory leak?
Not sure what that cause is, but it's happened twice (and by twice, I mean in two seperate games) since the new patch rolled in (Which has been plagued by numerous 'riot patch failed to install or load' correctly in the days leading up to, and once or twice after the patch actually went live.)
While it hasn't impacted gameplay in terms of actually slowing the game down, my game HAS been minimized at inconvenient times by an OS prompt recommending league be closed due to the amount of memory it's taking up.