Common, Longstanding Client Bugs
Here is a short list of frustrating bugs that happen on a daily basis to me or my friends. If the bug wasn't experienced by me personally and you need more info, I can get them to post here for you.
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Client freezes in champ select preventing lock-in or rune changes (occurrence usually only on friend's computer, <10% chance; <1% chance on rest I know)
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Loot screen is blacked out until you get off and then go back in (occurrence all people I've talked, almost all the time)
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Tell the game not to save rune page after a leaver while making runes (or if you don't finish in time) and it switches back to previous rune categories but leaves no runes selected on primary (occurance all the time at least on my computer)