If you go deep enough in a game and get to 8-9 champs you can mitigate assassins, even when there are 6. You have to make sure you are putting your least valuable champs on the back line so your carries, for example, dont get blown up. Unlike the yordles and glacials assassins are of course the easiest to get 6, as you can get 6 of the 7 fairly early in game. Now weather they all drop enough to get you at least 2 stars on all is something completely different. Even with the 6 bonus a one star assassin later in the game does negligible damage.
Getting 6 Yordles and building them up, particularly the Gnar or getting a solid glacial comp, Sejuani and Anivia, is no sure thing. Getting late enough into game to get them all to at least 2 star and having the right champs with the right items is the exception rather than the rule.
Im currently making my way up the ladder, Gold 4. I was Iron 2 earlier in the week. Anyway, due to consistency the people, myself included who are placing are getting fairly diverse synergies, 4-5 of them, unless they get really lucky with rolls have only 2 star champs, and are going for 8-9 or more champs, if they get a force of nature.
Sure there are outliers where everything goes your way and you get those champs early enough to build them up. However, if you are using that type of strat every single game you are going to not place much more often than you will place.
My observations only. Take it for what its worth.