GUYS, GUYS! I just found this link someone posted, Ill put the info here:
I don't know how to use imgur or anything, but I'll show you certain times to pause at during this "Ekko: Seconds" video.
https://www.youtube.com/watch?v=FtEpp9lkfxA
Some of the stuff said on here is speculation and just random things I found that intrigued me about the video. alot of the information may not be connected, but I believe some of it is.
The architecture and setting of the video look like what Zaun is described as. I believe it may be the subterranean levels below Zaun which is where Twitch lives and also which is supposedly severely polluted (which explains green smoke at 0:40). Also, Zaun is a place hailed for its techmaturgy and alchemy. The bioforged behemoth attacking Ekko would make sense to be in Zaun.
At 0:09, one can see 2 pictures of a man in a turban and an eyepatch: One in the top of screen in the middle & another on the panel in the middle of the screen at the bottom. I've done research into the lore of Zaun and Piltover and can't find anything on anyone with an eyepatch. The only champion (besides Rengar) with one would've been Urgot before his reconstruction WHICH WAS IN ZAUN.
So now we have established that the setting is in the underground sewer levels of Zaun, we can move onto the characters depicted in the mural and Ekko himself.
Zaun is stylized to be a biopunk counterpart to the steampunk Piltover. Jinx's clothes are described, by Piltover citizens, as being that which is common style in Zaun. Ekko has the same mixture of grunge and bio/steampunk that Jinx has.
At 0:21, one can see a picture taped to the face (which is believed to be Jinx because of blue hair, pale face, and creepy smile) that shows someone with short hair and goggles on forehead. Vi wears goggles on her forehead and has short hair.
On the panel parallel to the "Jinx" panel is a girl with a fuller face and purple hair. Being that Jinx and Vi are sisters, this definitely could be Vi. Jinx and Vi's lore both talk about how they were affiliated with a ragtag group of criminals when they were younger. Being that Piltover is right across Bluewind Bay from Zaun, it's very possible that Vi and Jinx would've been affiliated with Ekko.
At 0:22, one can see that all of the smaller painted faces on the mural at center-screen include one with spiky white hair at the bottom right. We can assume that this is Ekko's painting of himself. Who are the others? Well, I have heard that the one with goggles over the eyes could possibly be Viktor, which would make sense because Viktor is head of the Techmaturgy college in Zaun. As far as the other faces, we don't know who they are. Also, there are random doodles on the walls with insane faces akin to those which Jinx draws on her bombs and on walls.
At 0:36 in the video, on the crosshilt of Ekko's blade is seen the letters XII. What other Piltover native do we know that has something with roman numerals? Oh yeah, Vi! When Jinx was being teased, she vandalized Vi's champion page on the official League of Legends website and signed it "X was here!". X is the roman numeral for 10. Vi was number 6 in the group of ragtag orphans, Jinx was number 10, and Ekko was number 12.
At 0:40, one can see the full mural behind Ekko. The evidence shown above affirms the idea that Jinx is the big face on the left and Vi (purple hair) on the right.
TL;DR - Ekko lives in the Zaun subterranean sewers, where he and other orphans/ruffian kids would stay in community and support each other. The other orphans have all grown and moved on to other things in their lives. These orphans include but are not limited to Viktor (boy with goggles), Vi (mural on right), and Jinx (mural on left), and others who are depicted but not shown. His ability to control time causes him to not age (maybe) and that is the reason he appears so young compared to the other orphans. That is also the reason he has pictures of these orphans when they were younger.
Thanks for reading!
Edit: I got back from class and am adding stuff which I didn't have time for before.
Edit: Wanted to mention the clothing choice.
Edit: Added Jinx's number in the group of orphans
Edit: Took out the sister references since they are unconfirmed
Edit: Thanks to /u/iamwumbologist for creating this google doc with some of the evidence I've compiled so far. https://docs.google.com/document/d/1QwQxukHycaljonQem2w4VSKxeffUTXCmFf-WsHyzfoc/edit?usp=sharing